Dictionary Meaning and Definition on 'Collagenase'
n : any enzyme that catalyzes the hydrolysis of collagen and
Wikipedia Meaning and Definition on 'Collagenase'
Collagenases are enzymes that break the peptide bonds in collagen.
They assist in destroying extracellular structures in pathogenesis of bacteria such as Clostridium. They are an exotoxin (a virulence factor) and help to facilitate the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs.
Collagen, a key component of the animal extracellular matrix, is made through cleavage of pro-collagen by collagenase once it has been secreted from the cell. This stops large structures from forming inside the cell itself.
Collagenase production can be induced during an immune response, by cytokines that stimulate cells such as fibroblasts and osteoblasts, and cause indirect tissue damage.[See more about Collagenase at Dictionary 3.0 Encyclopedia]
Words and phrases related to 'Collagenase'
Collagenase Sample Sentences in News
- Research and Markets: World Collagenase (CAS 9001-12-1) Market Research Report
Research and Markets has announced the addition of the "Collagenase Market Research Report 2013" Read more on this news related to 'Collagenase'
- BioSpecifics Technologies Corp. Reports Fourth Quarter and Full Year 2013 Financial Results
LYNBROOK, N.Y., March 6, 2014 /PRNewswire/ -- BioSpecifics Technologies Corp. (NASDAQ: BSTC), a biopharmaceutical company developing first in class collagenase-based products marketed as XIAFLEX ® in the ... Read more on this news related to 'Collagenase'
- Auxilium Pharmaceuticals, Inc. Announces The FDA Acceptance Of Application Requesting Approval Of XIAFLEX® For The ...
CHESTERBROOK, Pa., Feb. 24, 2014 /PRNewswire/ -- Auxilium Pharmaceuticals, Inc. (AUXL), a fully integrated specialty biopharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has accepted the Company's submission of a supplemental Biologics License Application (sBLA) requesting approval of XIAFLEX (collagenase clostridium his Read more on this news related to 'Collagenase'